Home alone is not an option
You should never leave your puppy alone for any length of time. According to the RSPCA, more than one million dogs become distressed, noisy and destructive, often messing the house, when they are left alone. So if you're going away on holiday, or even just for the weekend, please don't let your arrangements get in the way of your pet's needs. It makes sense to plan ahead.
Kennels: Put your dog in a reputable boarding kennel and you'll be assured of reliable care and attention in a pet-friendly environment run by people who love dogs and know what they're doing. All they will ask of you is an up-to-date vaccination certificate. Also make sure they or you have current pet insurance, just in case your pet needs emergency care in your absence.
Your vet will be able to advise upon the best kennels in your area.
Friends: You might be fortunate enough to have friends, or family, who'll offer to stay and look after your house, and your puppy, while you're away. But make sure they know what's involved and that they will get on with your pet. This is an ideal solution should your pet find it too unsettling to be away from home.